Top News  Drug Safety Issues UK-MHRA Drug-Related Suicide Reports_Yellow Card
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UK-MHRA Drug-Related Suicide Reports_Yellow Card |
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Wednesday, 01 March 2006 |
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The UK adverse event drug reporting system utilizes the Yellow Card system for filing reports.
It is estimated to represent 1 in 100 adverse drug events that occur. However, as there is no control, the number of incidents do not inform us about the rate at which these events occured or possible contributing factors other than the drug. SUICIDE ACCOMPLISHED MHRA stats from Yellow Cards 2004 Drug Substance | No of Reports | | 1 fluoxetine | 62 | | 2 paroxetine | 38 | | 3 clozapine | 27 | | 4 venlafaxine | 17 | | = 5 sertraline | 15 | | = 5 isotretinoin | 15 | | =7 citalopram | 9 | | =7 dothiepin | 9 | | =7 moclobemide | 9 | | = 10 risperidone | 8 | | = 10 zopiclone | 8 | | 12 olanzapine | 7 | | = 13 amitriptyline | 6 | | = 13 mefloquine | 6 | | = 13 quetiapine | 6 | | = 16 fluphenazine | 5 | | = 16 fluvoxamine | 5 | | = 18 bupropion | 4 | | = 18 diazepam | 4 | | = 18 thioridazine | 4 | NON-ACCIDENTAL OVERDOSE Drug Substance | No of Reports | | 1 paroxetine | 36 | | 2 olanzapine | 29 | | = 3 paracetamol | 28 | | = 3 venlafaxine | 28 | | = 5 bupropion | 17 | | = 5 clozapine | 17 | | = 5 fluoxetine | 17 | | 8 sertraline | 15 | | 9 citalopram | 14 | | = 10 carbamazepine | 9 | | = 10 codeine | 9 | | =12 amitriptyline | 8 | | =12 dothiepin | 8 | | =12 zopiclone | 8 | | =12 dextropropoxyphene | 8 | | 16 quetiapine | 7 | | 17 moclobemide | 6 | OVERDOSE N.O.S. Drug Substance | No of Reports | | 1 clozapine | 109 | | 2 venlafaxine | 50 | | 3 paroxetine | 41 | | 4 fluoxetine | 35 | | 5 paracetamol | 29 | | 6 bupropion | 26 | | = 7 citalopram | 24 | | = 7 zopiclone | 24 | | 9 olanzapine | 19 | | = 10 dothiepin | 18 | | = 10 sertraline | 18 | | 12 tramadol | 16 | | 13 quetiapine | 14 | | 14 amitriptyline | 13 | | = 15 aspirin | 11 | | = 15 carbamazapine | 11 | | = 15 diazepam | 11 | | 18 diamorphine | 10 | | = 19 dihydrocodeine | 8 | | = 19 risperidone | 8 | SUICIDAL IDEATION Drug Substance | No of Rpts | | 1 fluoxetine | 125 | | 2 bupropion | 74 | | 3 paroxetine | 57 | | 4 isotretinoin | 18 | | 5 mefloquine | 17 | | = 6 citalopram | 11 | | = 6 efavirenz | 11 | | = 6 mirtazapine | 11 | | = 6 sertraline | 11 | | = 6 venlafaxine | 11 | | 11 zopiclone | 8 | | = 12 medroxyprogesterone | 7 | | = 12 oestradiol | 7 | | = 12 topiramate | 7 | | = 15 levonorgestrel | 6 | | = 15 nefazadone | 6 | | = 15 norethisterone | 6 | | = 15 simvastatin | 6 | | = 19 amlodipine | 5 | | = 19 atenolol | 5 | | = 19 clarithromycin | 5 | | = 19 etoricoxib | 5 | | = 19 fluvoxamine | 5 | | = 19 gabapentin | 5 | | = 19 lamotrigine | 5 | | = 19 levetiracetam | 5 | | = 19 rofecoxib | 5 | |
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